The Gene Wiki was established to transfer information on human genes from scientific resources to Wikipedia stub articles. [1] [2] [3]

The Gene Wiki project aussi Initiated publication of gene-specific review items in the journal Gene , together with the editing of the gene-specific pages in Wikipedia. [4]

Proect goals and scope

Number of gene articles

The human genome contains an estimated 20,000-25,000 protein-coding genes . [5] The aim of the Gene Wiki project is to create seed articles for each notable human gene, that is, every gene whose function has been assigned in the peer-reviewed scientific literature. Approximately half of human genes have assigned function, therefore the total number of articles seeded by the Gene Wiki project would be expected to be in the range of 10,000-15,000. To date, approximately 11,000 articles have been created or augmented to include Gene Wiki project content. [6]

Expansion

Once seed products-have-been ESTABLISHED, the hope and expectation Is That thesis will be annotated and expanded by editors ranging in experience from the lay audience to students to professionals and academics. [1]

Proteins encoded by genes

The majority of genes encode proteins and hence the function of the corresponding protein. In addition to including basic information about the gene, the project also includes information about the protein encoded by the gene.

Gene Wiki generated content

Stubs for the Gene Wiki project are created by a bot and links to Contain The Following primary gene / protein databases:

  • HUGO Gene Nomenclature Committee – official gene name
  • Enter – Gene database
  • OMIM (Mendelian Inheritance in Man) – database that catalogs all the known diseases with a genetic component
  • Amigo – Gene Ontology
  • HomoloGene – gene homologs in other species
  • SymAtlasRNA – gene expression pattern in tissues [7]
  • Protein Data Bank – 3D structure of protein encoded by the gene
  • UniProt ( uni versal prot ein resource) – a central repository of protein data

See also

  • Portal: Gene Wiki / Other Wikis external to Wikipedia

References

  1. ^ Jump up to:b Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI (July 2008). “A Gene Wiki for Community Annotation of Gene Function” . PLoS Biol . 6 (7): e175. PMC  2443188  . PMID  18613750 . Doi : 10.1371 / journal.pbio.0060175 .
  2. Jump up^ Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI. “SciVee Publishing: A Gene Wiki for Community Annotation of Gene Function” . Archived from the original on 2010-07-24 . Retrieved 2008-11-19 .
  3. Jump up^ Huss JW; Lindenbaum P; Martone M; et al. (January 2010). “The Gene Wiki: community intelligence applied to human gene annotation” . Nucleic Acids Res . 38 (Database issue): D633-9. PMC  2808918  . PMID  19755503 . Doi : 10.1093 / nar / gkp760 .
  4. Jump up^ Tsueng G, Good BM, Ping P, Golemis E, Hanukoglu I, van Wijnen AJ, Su AI (May 2, 2016). “Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome.” Gene . 592 (2): 235-8. PMID  27150585 . Doi : 10.1016 / j.gene.2016.04.053 .
  5. Jump up^ Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES (December 2007). “Distinguishing protein-coding and noncoding genes in the human genome” . Proc. Natl. Acad. Sci. USA . 104 (49): 19428-33. PMC  2148306 . PMID  18040051 . Doi : 10.1073 / pnas.0709013104 .
  6. Jump up^ “Gene Wiki Pages” . Pages that link to {{ PBB }} . Wikipedia, the free encyclopedia . Retrieved 2015-01-27 .
  7. Jump up^ Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB (April 2004). “A gene atlas of the mouse and human protein-encoding transcriptomes” . Proc. Natl. Acad. Sci. USA . 101 (16): 6062-7. PMC  395923  . PMID  15075390 . Doi : 10.1073 / pnas.0400782101

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